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The suggestion of a negative association with FEV1 at higher exposure levels could reflect mixing of this putative stretch/training effect with a second mechanism operating on a different time-exposure scale

Although the true mechanism remains unclear, we posit that arterial stiffness explains the blood pressure subtraction difference from baseline between the hypertensive and nonhypertensive groups 26

PMID 32246394

Nicotine Addiction Compared to Other Substances People often ask, How addictive is nicotine compared to other drugs? The answer is startling: nicotine ranks among the hardest substances to quit often more difficult than heroin, cocaine or alcohol

According to critics of the tobacco industry, the holes create a flexible dosing system that allows addicted smokers to maintain the tar and nicotine levels they crave while believing they are receiving lower, safer doses